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Advancing Analytics

We develop and combine technologies into four-dimensional analytical methods for health research. Our goal: With our analytics for precision medicine, we want to contribute to optimising the prevention, diagnosis and therapy of various diseases.

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Research Programmes

In our four programmes, we conduct research on various interdisciplinary projects. In one of our research programmes, for example, we combine analytical procedures and develop multi-method concepts in order to elucidate disease mechanisms and identify potential therapeutic approaches - always with a clear application purpose for the following preclinical research.

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ISAS Kompakt

17th January 2025

What do you do at ISAS, Lennart?

What fascinates you about your work as a software engineer? And and Why are you engaged in the works council? Lennart Kowitz answers these and other questions in ISAS Kompakt.

Portrait of Lennart Kowitz.
15th January 2025

Dorit Günther appointed to the ISAS Executive Board

Günther will assume the role of Chief Financial Officer of ISAS.

Portrait von Dorit Günther.
3rd January 2025

Valuable Connections: Dr Julia Lill

Dr Julia Lill conducted research at ISAS from 2020 to 2021. She is now a Senior Scientist in the Cancer Immunology team at BioNTech in Cambridge (USA). The immunologist reports on how her time at ISAS brought her to this field of research and the relevance of a functional network in the ISAS compact series ‘Valuable Connections’.

A portrait of Julia Lill.
10th December 2024

Xiaowei Xu Will Join ISAS as a Humboldt Fellow

As a fellow of the Alexander von Humboldt Foundation, Prof Dr Xiaowei Xu will be conducting research at ISAS from February 2025. In this interview, he talks about his work on artificial intelligence in health research and what he plans to do in Dortmund.

Portrait of Prof Dr Xiaowei Xu.
21st November 2024

PODCAST »NACHGEFORSCHT – DIE LIVESCHALTE INS LABOR« Episode 10: Resource Awareness in Biomedical Image Analysis

Dr Jianxu Chen heads the junior research group AMBIOM - Analysis of Microscopic BIOMedical Images at ISAS. In the first English-language episode of »NACHGEFORSCHT - DIE LIVESCHALTE INS LABOR«, he talks about his path from mathematics to the life sciences and how he wants to make the analysis of biomedical data more sustainable - on many levels.

15th November 2024

Valuable Connections: Prof Dr René Zahedi

Prof Dr René Zahedi headed a junior research and later regular research group at ISAS from 2008 to 2017. He now lives, conducts research and teaches in Canada - the research network from his time at ISAS, however, continues to accompany the scientist in his work. Zahedi is one of the colleagues who will provide an insight into the valuable connections within and outside the institute in the following weeks and months.

Prof. Dr. René Zahedi.
8th November 2024

Using the Russian Doll Principle to Analyse Biological Structures

In the “AI-assisted imaging of large tissues” project, several ISAS research groups are working on combining various microscopic and mass spectrometric methods. Much like looking at a Russian doll, the team looks deeper into the biological structures of a sample with each step.

Flora Weber at the lightsheet fluorescence microscope.
31st October 2024

AI in Healthcare: Why Is it Better to Think Small Instead of Big?

Sustainability is an important topic when it comes to artificial intelligence in health research. A group of international researchers, including from ISAS, has been working on this topic and published a Perspective in Nature Machine Intelligence. In the interview, Prof Dr Yiyu Shi talks about the resource problem and possible solutions.

Portrait von Prof. Dr. Yiyu Shi.
25th October 2024

Valuable Connections: Dr Saskia Venne

Dr Saskia Venne completed her doctorate at ISAS from 2012 to 2016. Today she is a team leader at Boehringer Ingelheim Pharma. In this interview, she is the first to provides an insight into the valuable connections in- and outside the institute that current and former ISAS researchers will be reporting on in ISAS Kompakt over the coming weeks.

Dr. Saskia Venne.
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Publications

Antibodies, Vol. 14, No. 3, 2025

Döring S, Weller MG, Reinders Y, Konthur Z, Jaeger C.

Challenges and Insights in Absolute Quantification of Recombinant Therapeutic Antibodies by Mass Spectrometry: An Introductory Review

Pharmacological Research, Vol. 211, 2024, P. 107558

Brand T, Baumgarten BT, Denzinger S, Reinders Y, Kleindl M, Schanbacher C, Funk F, Gedik N, Jabbasseh M, Kleinbongard P, Dudek J, Szendroedi J,…

From Ca2+ dysregulation to heart failure: β-adrenoceptor activation by RKIP postpones molecular damages and subsequent cardiac dysfunction in mice carrying mutant PLNR9C by correction of aberrant Ca2+-handling

https://doi.org/10.1016/j.phrs.2024.107558

Biological Imaging, Vol. 4, 2024, P. e16

Zhou Y, Sollmann J, Chen J.

Deep-learning-based image compression for microscopy images: An empirical study

https://doi.org/10.1017/S2633903X24000151

Polymers for Advanced Technologies, Vol. 35, No. 12, 2024

Al-Bataineh Q, Ahmad A, Migdadi AB, Telfah A.

Effect of Ionic-Electronic Coupling on the Percolation Phenomenon of Polymer/Reduced Graphene Oxide Nanocomposite Films

https://doi.org/10.1002/pat.70024

ISME Communications, Vol. 2024, No. 4(1), 2024

Hellwig P, Kautzner D, Heyer R, Dittrich A, Wibberg D, Busche T, Winkler A, Reichl U, Benndorf D.

Tracing active members in microbial communities by BONCAT and click chemistry-based enrichment of newly synthesized proteins

https://doi.org/10.1093/ismeco/ycae153

Applied Materials Today, Vol. 2024, No. 41, 2024

Höving S, Ahlmann J, Schomacher J, Schiller A, Franzke J.

Continuous fiber printing of a modular heater for ion mobility spectrometry

https://doi.org/10.1016/j.apmt.2024.102501

Journal of the American Society for Mass Spectrometry, Vol. 35, No. 12, 2024

Höving S, Song H, Speicher L, Schiller A, Franzke J.

Compact Plasma Ionization for Ion Mobility Spectrometry Using a 4.3 MHz Miniature Tesla Coil

https://doi.org/10.1021/jasms.4c00360

Molecules , Vol. 2024, No. 29, 2024

Manis C, Casula M, Roos A, Hentschel A, Vorgerd M, Pogoryelova O, Derksen A, Spendiff S, Lochmueller H, Caboni P.

Ion Mobility QTOF-MS Untargeted Lipidomics of Human Serum Reveals a Metabolic Fingerprint for GNE Myopathy

https://doi.org/10.3390/molecules29215211

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