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Advancing Analytics

We develop and combine technologies into four-dimensional analytical methods for health research. Our goal: With our analytics for precision medicine, we want to contribute to optimising the prevention, diagnosis and therapy of various diseases.

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Research Programmes

In our four programmes, we conduct research on various interdisciplinary projects. In one of our research programmes, for example, we combine analytical procedures and develop multi-method concepts in order to elucidate disease mechanisms and identify potential therapeutic approaches - always with a clear application purpose for the following preclinical research.

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ISAS Kompakt

21st November 2024

PODCAST »NACHGEFORSCHT – DIE LIVESCHALTE INS LABOR« Episode 10: Resource Awareness in Biomedical Image Analysis

Dr Jianxu Chen heads the junior research group AMBIOM - Analysis of Microscopic BIOMedical Images at ISAS. In the first English-language episode of »NACHGEFORSCHT - DIE LIVESCHALTE INS LABOR«, he talks about his path from mathematics to the life sciences and how he wants to make the analysis of biomedical data more sustainable - on many levels.

15th November 2024

Valuable Connections: Prof Dr René Zahedi

Prof Dr René Zahedi headed a junior research and later regular research group at ISAS from 2008 to 2017. He now lives, conducts research and teaches in Canada - the research network from his time at ISAS, however, continues to accompany the scientist in his work. Zahedi is one of the colleagues who will provide an insight into the valuable connections within and outside the institute in the following weeks and months.

Prof. Dr. René Zahedi.
8th November 2024

Using the Russian Doll Principle to Analyse Biological Structures

In the “AI-assisted imaging of large tissues” project, several ISAS research groups are working on combining various microscopic and mass spectrometric methods. Much like looking at a Russian doll, the team looks deeper into the biological structures of a sample with each step.

Flora Weber at the lightsheet fluorescence microscope.
31st October 2024

AI in Healthcare: Why Is it Better to Think Small Instead of Big?

Sustainability is an important topic when it comes to artificial intelligence in health research. A group of international researchers, including from ISAS, has been working on this topic and published a Perspective in Nature Machine Intelligence. In the interview, Prof Dr Yiyu Shi talks about the resource problem and possible solutions.

Portrait von Prof. Dr. Yiyu Shi.
25th October 2024

Valuable Connections: Dr Saskia Venne

Dr Saskia Venne completed her doctorate at ISAS from 2012 to 2016. Today she is a team leader at Boehringer Ingelheim Pharma. In this interview, she is the first to provides an insight into the valuable connections in- and outside the institute that current and former ISAS researchers will be reporting on in ISAS Kompakt over the coming weeks.

Dr. Saskia Venne.
21st October 2024

Between Progress and Footprint: Artificial Intelligence in Healthcare

The potential applications of artificial intelligence in healthcare are constantly increasing. However, with ever better and faster models, the question of sustainability is also coming to the fore. A group of international researchers, including Dr Jianxu Chen from ISAS's AMBIOM group, has been looking into the increased consumption of resources and possible solutions to the impending sustainability problem.

Dr. Jianxu Chen (links) und Prof. Dr. Yiyu Shi im Foyer des ISAS.
15th October 2024

Science Meets Art: Immersion in the Secret World of the Immune System

Diving into the smallest structures of the heart via microscope images? This was possible at the first Dortmund Science Night. "The secret world of the immune system", the immersive 3D experience by storyLab kiU at Fachhochschule Dortmund University of Applied Sciences and Arts and ISAS, gave visitors the chance to experience immune cells up close after a heart attack.

Das Foto zeigt (v.l.n.r.) Dr. Malte Roeßing, Dr. Ali Ata Tuz, Lara Janz, Flora Weber, Sara Regein und Cheyenne Peters vor dem Stand des ISAS bei der Science Night 2024.
20th September 2024

"Book a Scientist": Register Now for a Virtual Chat with Researchers

The format "Book a Scientist" offers those interested in science the opportunity to book individual appointments with researchers within the Leibniz Association. Among them are two ISAS researchers. Their topics are "overzealous" immune cells after a heart attack and animal experiments and their alternatives.

Book a Scientist.
10th September 2024

Fascinating Insights: Virtual World in the Classroom

What actually is reality? How do we perceive our environment? And how can augmented reality support researchers in their work? Along with class 3a of the Don Bosco elementary school in Bochum, two ISAS researchers explored these questions.

Marie steht im Klassenzimmer und trägt eine VR-Brille. In den Händen hält sie jeweils einen Controller.
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Publications

Molecules , Vol. 2024, No. 29, 2024

Manis C, Casula M, Roos A, Hentschel A, Vorgerd M, Pogoryelova O, Derksen A, Spendiff S, Lochmueller H, Caboni P.

Ion Mobility QTOF-MS Untargeted Lipidomics of Human Serum Reveals a Metabolic Fingerprint for GNE Myopathy

https://doi.org/10.3390/molecules29215211

Science, Vol. 2024, No. 6721, 2024, P. 516-525

Kraft F, Rodriguez-Aliaga P, Yuan W, Franken L, Zajt K, Hasan D, Lee T, Flex E, Hentschel A, Innes AM, Zheng B, Julia Suh DS, Knopp C, Lausberg E,…

Brain malformations and seizures by impaired chaperonin function of TRiC

https://doi.org/10.1126/science.adp8721

Redox Biology, Vol. 2024, No. 77, 2024

Raabe J, Wittig I, Laurette P, Stathopoulou K, Brand T, Schulze T, Klampe B, Orthey E, Cabrera-Orefice A, Meisterknecht J, Thiemann E, Laufer SD,…

Physioxia rewires mitochondrial complex composition to protect stem cell viability

https://doi.org/10.1016/j.redox.2024.103352

Biomedicines, Vol. 12, No. 10, 2024

Lang A, Oehler D, Benkhoff M, Reinders Y, Maike B, Shahrjedi K, Kaldirim M, Sickmann A, Dannenberg L, Polzin A, Pfeiler S, Kelm M, Grandoch M, Jung…

Mitochondrial Creatine Kinase 2 (Ckmt2) as a Plasma-Based Biomarker for Evaluating Reperfusion Injury in Acute Myocardial Infarction

https://doi.org/10.3390/biomedicines12102368

Chemistry-A European Journal, Vol. 30, No. 56, 2024, P. e202402685

Squarcina A, Maier P, Senft L, Vignane T, Filipovic MR, Ivanovic-Burmazovic I.

Unlocking Selective Anticancer Mechanisms: Dinuclear Manganese Superoxide Dismutase Mimetics Combined with Pt(II) Complexes

https://doi.org/10.1002/chem.202402685

Spectrochimica Acta Part B-Atomic Spectroscopy, Vol. 2024, No. 221, 2024

Song H, Tian C, Speicher L, Ahlmann N, Foest D, Höving S, Brandt S, Niu G, Franzke J.

Excitation and ionization of a diagnosis gas in front of the flexible μ tube plasma and in a diagnosis tube

https://doi.org/10.1016/j.sab.2024.107052

JMIR Serious Games, Vol. 12, 2024, P. e52785

Egger J, Gsaxner C, Luijten G, Chen J, Chen X, Bian J, Kleesiek J, Puladi B.

Is the Apple Vision Pro the Ultimate Display? A First Perspective and Survey on Entering the Wonderland of Precision Medicine

https://doi.org/10.2196/52785

Journal of Neuromuscular Diseases, Vol. 11, No. 5, 2024, P. 1131-1137

Roos A, Häusler M, Kollipara L, Topf A, Preusse C, Stucka R, Nolte K, Strom T, Berutti R, Jiang X, Koll R, Lochmüller H, Schacht SM, Zahedi RP, Weis…

HNRNPA1 de novo Variant Associated with Early Childhood Onset, Rapidly Progressive Generalized Myopathy

https://doi.org/10.3233/JND-240050

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